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Should there be music playing in the background when I'm speaking? What about when this person is talking? What song would be appropriate here? What do I want the listener to feel? Choosing the best sound selection and when in a podcast depends on many factors. Sound isn't just limited to music either, there are natural pops, "room noises," and voices.
Natural pops have a huge roll in creating a specific scene or location in the listener's mind. If you have birds chirping and the wind blowing then the audience gets a feeling of being outside. Add in some dogs barking and maybe a few soft conversations and the listener feels like they're in a park. Room noise is like the silence you experience when in a... well a room. It's not perfect silence, it's comforting silence. Voices are pretty self explanatory, but it's the sounds you combine with them that are important.
It's no easy task to pick what goes together but when you get it right, audio makes all the difference in the world. Choose wisely.